Importantly, the molecular mechanisms involved in these effects are largely unknown, and here we perform the first genomic characterisation of the venom death pathway. The venoms of box jellyfish are mixtures of bioactive proteins that can cause potent haemolytic activity, cytotoxicity, membrane pore formation, inflammation, in vivo cardiovascular collapse and lethal effects in experimental animals 4, 5, 6. fleckeri envenoming can be life-threatening, however for the vast majority of cases patients suffer extreme pain and local tissue destruction 2, 3. Contact with jellyfish tentacles will trigger the explosive release of nematocysts that deliver potent and rapid-acting venom into the victim or prey. The box jellyfish, Chironex fleckeri, is one of the most venomous animal in the world 1. These results highlight the power of whole genome CRISPR screening to investigate venom mechanisms of action and to rapidly identify new medicines. We also discover a venom antidote that functions up to 15 minutes after exposure and suppresses tissue necrosis and pain in mice. Informatics analysis of host genes required for venom cytotoxicity reveal pathways not previously implicated in cell death. Targeting ATP2B1 prevents venom action and confers long lasting protection. We identify the peripheral membrane protein ATP2B1, a calcium transporting ATPase, as one host factor required for venom cytotoxicity. ![]() Here we perform molecular dissection of a jellyfish venom-induced cell death pathway by screening for host components required for venom exposure-induced cell death using genome-scale lenti-CRISPR mutagenesis. Despite rapid and potent venom action, basic mechanistic insight is lacking. ![]() The box jellyfish Chironex fleckeri is extremely venomous, and envenoming causes tissue necrosis, extreme pain and death within minutes after severe exposure.
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![]() If a mild, fresh scent is what you’re after, we also have cotton and aquatic scents. Want something to calm you down in the evening before bed? Aromas like cocoa and honey will soothe your senses for the ultimate relaxation. If you’re looking to be wakened up during your morning shower, we offer exhilarating scents like lemongrass and moringa to give you a burst of freshness. That’s why at NIVEA, we carefully select fragrances that complement our body cleansing products, and why there is such a large variety of fragrances you can choose from – from fruity and floral, to citrusy and marine. It’s no secret that fragrances can strongly affect our mood. In addition to our body cleansing products with innovative twists, you’ll always find all the highly effective classics you know and love. Plus, our new addition to the body cleansing line is formulated with clay for a particularly deep and purifying cleanse. Furthermore, we offer shower oils and creams with oil pearls to provide indulgently intensive moisture. In addition to plant oils and aloe vera, the star of the cleansing bar is Coenzyme Q10 (aka CoQ10), an effective ingredient that tackles free radicals and soothes stressed skin. And body cleansing mousses that have light-as-air textures to gently cleanse. The best bar for sudsing up in the shower is DHC's Q10 Body Soap. So that’s why in our body cleansing range, we offer unique in-shower body lotions that can be used in the shower to save you time in the mornings while leaving your skin feeling completely soft and moisturized. With a hint of fragrance that is left behind after your shower, you are sure to feel fresh and clean for the whole day. ![]() The specialists at NIVEA are always looking for new, innovative textures and ingredients to deliver the results you’re searching for. But within NIVEA’s product range, we offer so much more. You may think that when it comes to body cleansing products, there’s not much more than creams and gels. ![]() The same can’t be said for Fort Tuthill in Flagstaff, Arizona though. And while it may not be perfect, my prediction is that Overland Expo East is unlikely to outgrow Infinity Downs in Arrington, Virginia. Any way you slice it, site selection for large scale outdoor events always comes down to compromises, especially for an outdoor focused event as diverse as this. Through the years, I’ve watched Overland Expo move around to a few different venues as it grew. It’s been said that the first rule of business is location. This was the first in a series of jaw dropping vehicle builds to catch my eye at Expo East. I’ve seen some dialed in 60’s over the years, and the attention to detail and overall wow factor here is second to none. Speaking of Force Protector Gear, check out the Adapter Shade Panel on the rear hatch and the rest of the awesomeness that is the Goose Gear 60 Series Land Cruiser build. We even went so far as to invite a special guest to help us with inclement weather preparedness this year – BIG thanks to Andy Nichols and Force Protector Gear for helping us provide ample shelter at our booth for our staff and the Overland Expo attendees. As the saying goes, there is no such thing as bad weather, just bad gear. Being veterans of many previous Eastern events like Mudderland Expo East, and with big rain in the forecast, we were ready for anything. The weather forecast was typical for this region in the fall – anything was possible. Before long, the rest of our crew started drifting in and we we had Old Glory flying high in short order. At the booth, our IT maestro Greg Henle was already set up in his Shiftpod. ![]() The onboarding process was much improved from what I saw at Overland Expo Mountain West out in Colorado a few weeks back and we were thankful for the soft landing here. Underway once again, after a few more hours on the road in Virginia and a stop at Yoder’s country market for last minute provisioning, we arrived at the event site and were quickly checked in. Mercifully, Tim chose to travel light with only four steamer trunks and a sea bag, and we added his gear to the Jeep in the morning along with a big batch of his famous clam chowdah that would sustain us in camp at Overland Expo East.īig thanks to Tim and Diane Bleau for their outstanding hospitality at what I jokingly refer to as the Last Homely House in Occupied Northern Virginia (Tolkein references here for the unread). It was here at this bastion of hospitality and gastronomical wonders that Tim Bleau joined our merry band of Adventurists for the event. The kitchen was warm and inviting when this weary traveler arrived, and I enjoyed dinner, supper, breakfast, and second breakfast during my stay. With just one last layover at an undisclosed location in northern Virginia, I skipped lunch and pressed on towards friendly territory. Drifting north through the Carolinas in daylight and better weather with my favorite road trip playlist blasting, all was right in the world. It’s a great way to save some money on lodging if you’re traveling long distances like I do.įully rested and with hot coffee onboard, I broke camp just after daylight and rolled back out towards the hardball. I really enjoy adding locations to their crowd sourced map, and finding or updating featured ones as I travel. We have no affiliation with iOverlander, but I’m a big fan and have been using this app for a couple of years now as I’ve crisscrossed the lower 48. Rather than book a hotel along my route, I opted for some spontaneity by using the iOverlander app which helped me find a quiet, dispersed campsite just across the border in South Carolina. ![]() Crossing into Georgia at dusk, I headed through Atlanta in the general direction of the event site in Virginia. The drive north through Alabama was mostly uneventful save for a few absentminded drivers as I headed straight into torrential rains and buffeting winds. As usual, I left Northwest Florida a couple days early for a bit of overlanding and a much needed break from work before show time. Overlanding is different east of the Mississippi, and I was keen on seeing how the East Coast version of Expo was doing. Overland Expo East was to be our third Overland Expo event within the space of a few weeks, and it seemed like I had just returned from Colorado when it was time to go again. ![]() URL to SABnzbd ( HTTP included and portnumber where SABnzbd is installed) Usually this requires a portforward but this is outside of the scope of this documentation. When Sabnzbd needs to be accessed through the internet by Spotweb, this requires a setup on your router to make sure Spotweb can reach Sabnzbd directly. When the user also has the permission to use the Sabnzbd API, it allows the download panel. The NZB file is uploaded to Sabnzbd by Spotweb itself. This option is usually known as ‘push-sabnzbd’, its internal name and as used by the objectid. Now the user is able to select the granted download method using its’ preference screen. Select the checkbox before Use downloads manager API and save it.Go to the Userlist and click on the user you want to give this permission.Use the following as name: Use downloads manager API.Press the + sign at the bottom of this group list.If your chosen download method supports this, please add the following permission to your group. This is a way to check your download progress from another download client within Spotweb itself. Spotweb also supports a ‘download panel’. The ObjectID basically defines which type of NZB handling is allowed for users which are a member of this group. For the ‘ObjectID’ you enter the value ‘nzbget’ (without quotes). Add the ‘Download manager integration’-permission. Add this group, and click on the pencil icon in the ‘Permissions’-column. Add a new group by clicking on the ‘+’-button.Įnter a new group name – eg: ‘ NZB Handling – NZBGet’. Now open the ‘Admin panel’ and click on the tab ‘Grouplist’. To create a new group, login using a user with administrative permissions – the user ‘admin’ for example. However, we don’t suggest just adding everybody to the administrators group as this will expose your Spotweb installation.įor maximum control, you can create a separate security group for each of the (set of) NZB handling options you want to be able to grant access to. Whether these options are available depends on the permissions a user has, some operations can be ‘dangerous’ to be available for non-trusted users and are prohibited for several users.īy default all users which are a member of the ‘Administrators’ group, have access to all NZB handling options. Growl and OS X 10.Spotweb currently suppors the following NZB handling options:.Support for yEnc and UUEncode encoded downloads.NZB watch folder - add nzbs from a specific folder.RSS feed watcher - automate your downloads.Shutdown/sleep when all downloads are completed.Quick data checks using CRC32, SFV and PAR2.Post processing, parring, unnrarring, unzipping, joining.Optimize download size, smart-skipping Samples and par2 files.Cleans up your downloads after they are finished.Smart pre-checks for junk and passworded NZBs.Web and iPad interface included - works great on your tablet.Very efficient multi-server, multi-connection downloads.If you have any issues at all, contact us at Features Please note: You need a subscription to a usenet server or one from your Internet provider. NZBVortex is a small, efficient, and powerful NZB client for OS X, optimized for performance and ease of use-a usenet client which really takes the pain out of usenet downloading the most efficient way. Paths can be created by folding down sections of stairways to adjust levels, mixing and matching until you can make progress. The few puzzles that do use the pop-up formula show how nicely it could have worked. Solutions that do not embrace the pop-up creation at all. Or it just descends to rotating circles or counting symbols. Get a missing piece of a glyph by pulling tabs to raise and lower the water level in a well. Put some wolves to sleep by tinkling wind chimes, by pulling at tabs. Where every other puzzle adventure might have levers to pull, Tengami has tabs to pull. Sadly, it seems that it is my brain thinking of these ideas, as the game opts for primarily generic puzzling that mostly ignores the format. And given the concept, my brain immediately fizzled with the potential of unique puzzles presented by the format, where turning pages, pulling tabs and manipulating scenery could allow you to amend the environment to complete challenges. Presented as an impossible pop-up book, you move a paper character through pretty scenery, with nebulous aims of reaching glowy lights, and an ultimate goal of collecting flowers to rejuvenate a sad-looking wintry tree. (Although there are flaws with the PC port.) The biggest issue here is this is a game that never figured out how to be itself. The key flaws aren’t with the PC port, however. I’m not even vaguely sure what was done to the game, beyond perhaps improving resolutions, since. A hefty two and a half years on, our wish is finally granted, and Tengami has made its way onto Steam. The Indicade nominated puzzle adventure is immediately eye-catching, thanks to its Japanese pop-up book design, and took naturally to the iPad’s smooth-screened finger-tapping home. Schneidereit says the Tengami team particularly wanted to avoid the child-like aesthetic common to other games about paper crafting or real-world storybooks, and even experimenting with the patterned aesthetic of origami paper made the game look overstimulating.Since 2012 we’ve been keen to see Tengami on PC. The team built its own intensive technology that ultimately emulated the physics of complex pop-ups in lifelike ways that the player could open, close and interact with in order to guide a character through a world of cherry trees, subtle colors and lovely, minimalist textures. The team’s first step was actually to comb bookstores for hundreds of real-world pop-up books, and guides for how to make pop-up and papercraft, until they found one that explained the synchronization of fold systems in a way that truly showed them how to build what they wanted. Most importantly, a game set in a pop-up book isn’t something anyone’s broadly seen attempted before, in a climate where inventive concepts are crucial to success on the mobile marketplace. Another major influence on the team is the growing interactivity of reading in the mobile space, that sees increasing interactivity being applied to books, and apps that aim to make decision-based interactive experiences out of traditionally-static reading. Schneidereit says she’s been inspired by her experience working in Japan, and her desire to communicate her love of traditional Japanese art to other Westerners. There, she met her co-founder, former Rare director of gameplay Phil Tossell, and the pair established Nyamnyam in 2010. ![]() Often, these new studios are founded by talent with years of experience in traditional development that’s the case with UK-based Nyamyam, co-founded by Jennifer Schneidereit, who worked with Tokyo-based Acquire before joining long-standing UK-based studio Rare to work on Microsoft’s Kinect Sports games. Some of the most interesting prototypes and game demos I’ve had in recent months have been from indies developing for tablet devices the game development landscape is a massive and constant competition for attention, but I’ve been most impressed by small teams pushing the envelope with relatively-limited resources. But if about 80 percent of mobile games are free, that means 20 percent are premium, costing a dollar or two, which means less competition in the paid category currently when it comes to games with higher budgets, or with the art and design to be visible and competitive. The economics of mobile games are shifting, too - prevailing wisdom so far has led to most games being free, with some paid elements. Not only does it allow more vivid art to shine, but the intimacy of the lap-based screen can provide more tactile experiences, often designed for two hands instead of just one. The tablet has some of the breadth and built-in awareness of smartphones, but the larger screen is more than just a size increase, from a game design perspective. ![]() Its Pro version for Windows and Mac only, some of the stuff is limited to the Windows version only, and the This surely is out of reach of most home users, and only people with a real interest in advancing PDF authoringĪnd editing should consider the price tag. At USD89 for the standard edition, which lacks OCR and batch processing, and USD129 for the Pro edition, The somewhat bland looks, the biggest letdown of this program, notwithstanding, the big question is that of the Tools available, so it surely won't be boring. Inline text edits, or to be able to export parts of the document as images. PDF Studio Pro is a very decent program, and it does live up to its promise. Rather easy to navigate, and it should help you tame the program well. ![]() Time going through the menus and settings and checking all the available features. Some of the rest of the stuff may seem trivial, like the Loupe tool, but you really need to invest You can add media files to your documents, attachments, compare documents, and the list Moreover, you have the ability to sign your documents, and create yourĪnd still much more. You can selectively disable Javascript, or make the software PDF Studio Pro is also quite keen on security. This can be a great thing for fixing tiny typos, especially if you no longer have the You canĪctually select pieces of the article text and make changes, including font size, shape, color, spacing, andĮven the actual contents. Including several presets, or your own custom ones.įor me, the most impressive part is the ability to edit parts of the text embedded in the documents. You can add comments and notes, use auto-expanding textboxes with or withoutĪrrow pointers, stamps, geometric shapes, as well as mark text in multiple ways. The biggest focus is on the editing and collaboration tools, which means the program lets you massage your PDFĭocuments any which way you want. You can extract pages from the document, or export pages as images, which can be quite handy. You can do page range splits, blank page splits, or even use text markers. You do need aīit of time to figure out all the options and settings and slowly start exploring them.įor example, the Studio will let you split or join documents, so you do not need to go The truth is, PDF Studio has a lot of features, and it can be overwhelming just to try using it. ![]() So far, it behaved like any good PDF program. To see what PDF Studio Pro could do, I downloaded my own Kernel crash book and So definitely something worth considering. Get a generic kind of Java looks that feel outdated and take away from the underlying potential of this The GUI skin is not the prettiest, probably because it is designed to be common across all platforms, so you The self-update, plus homeĭirectory permissions are really good for common users. The problem of not managing the program through the default package manager. Then, it can also check for updates, which is quite neat, and allows you to go around You can setup the software in your home directory, so you do not even Which ought to be good for all platforms. Debian installer files are available, but the default download option is a generic shell script, I decided to try the program on Linux, using Salamander as the target Now, let's focus on the technical bits and pieces. As it happens, if you do own a key for PDF Studio ProĨ, you are eligible for a free upgrade to version 9, which includes form creation. Got a serial key for the Pro version of their software. Available for all major platforms,Īfter confirming the team was willing for me to go ahead in the case the review turned out to be negative, I Software comparison article, ability to edit content, and even OCR, which is always a hot topic. ![]() The notable selling points mentioned wereĪdvanced featured compared to Okular, which I played with in my Linux I was contacted by the PR person of the company behind PDF Studio, asking me to test and review their PDF software product. Must be directed to the appropriate software vendor. Qweas is providing links to LuckyWire for Mac 1.0 as a courtesy,Īnd makes no representations regarding LuckyWire for Mac or any other applications orĪny questions, complaints or claims regarding this application LuckyWire for Mac 1.0 Mac MP4 movie converter can convert video/audio filesīarcode Label software for Mac which Create up to 20 types of barcodes.įree Mac Media player for DVD, VCD, MPEG and DivX. Virtualization software for Intel-based MacsĪ religious take on the classic hangman word-guessing game.ĭVD Copier for Mac OS X copies DVD movies in 1:1 ratio quickly and easily Rip DVD to all popular video files on Mac OS X fast and easyĪCDSee for Mac graphics application supports Mac OS X and twain software.ĭVD Ripper for Mac, Video Converter for Mac and DVD Copy for Mac.Ī free, swift and smart Flash player for MAC. Rip DVD VOB to AVI, DVD to MOV for MAC,convert dvd to other video formatsĪ galactic war rages between two ancient civilizations. LuckyWire 5 1 30.4 k Downloads P2P à Velocidade Máxima Propaganda Última versão 1.0.0.2 Propaganda O LuckyWire é um serviço de download P2P graças ao qual podes baixar inúmeras músicas, vídeos, imagens e vários programas a uma velocidade vertiginosa. Ĭopy DVD movie for MAC, Copy DVD movie on MAC From there, you can use them in other programs.Ħ. All you need to do to use them is to know where you're saving your files to when you download them. You're lucky Wire didn't stick her gun in your face. It will auto-update your files in your iTunes to transfer to your iPod, iPhone, and such. That would not be consistent with what I know, Mac replied, his eyes locked on Axe. Luckywire for Mac already has built-in functionality with iTunes. This is a feature that you would have to pay for in Limewire PRO. We increase the productivity in your team while keeping your information private. Luckywire for Mac comes with turbocharged download speeds. Wire is the most secure collaboration platform. While most of all requested files can be found, there are limitations to what is available. First release is only in english (with exception of the MacOSX version which has partial translations. ![]() I would also greatly appreciate any assistance with translations, so they can be accurately multi-language. It can also be used to open torrent files and download their content. The LuckyWire OSX version no longer seems to be available for download. Sometimes you may find a file, sometimes you may not. LuckyWire is a peer-to-peer client that intends to help you find and download various files by connecting to multiple sources. Search results vary by which users are online. ![]() It is the fastest P2P program, and LuckyWire for Mac is FREE. The device uses the USB connection to recharge its battery and automatically pair with your Mac. Professor Dunn completed his undergraduate studies at Stanford University, followed by graduate studies with Günter Wagner at Yale, and postdoctoral work with Mark Martindale at the University of Hawaii. It gained a few viewers over the next week or so, and then, earlier this week, feminist scholar Sophie Lewis wrote a Twitter thread in which. He is the co-author of Practical Computing for Biologists, which helps more biologists become comfortable with computational methods. Netflix released My Octopus Teacher on September 4. He and his team address basic questions about siphonophore structure, growth, diversity, and evolution. In addition to his studies of broad patterns of diversity across distantly related animals, his lab also focuses on siphonophores, a group of about 185 species of open-ocean animals that include the Portuguese Man of War. My Octopus Teacher follows documentary film-maker Craig Foster as he dives in the ocean near his home on the southern shores of the Cape Peninsula to observe, document, touch and be touched by a. Much of his work is computational- developing methods and tools for analyzing evolutionary relationships and using those relationships to provide an integrated perspective on genomic and anatomical evolution. Ten years in the making, My Octopus Teacher began as a personal video project by South African filmmaker Craig Foster to rekindle his connection with nature by observing an inquisitive female mollusk while free-diving near Cape Town. After watching Pippa Ehrlichs film, you may find it manipulative, lacking real depth, until it slowly starts to grow on you. For more than a year Foster follows her on daily dives as she hunts for prey and evades her predators with an uncanny ingenuity that calls into question human assumptions of superior intelligence. Lab bench work includes studies of anatomy and genome function. My Octopus Teacher tells the story of the unusual bond between Foster and a wild octopus he encounters while freediving. According to National Geographic, the common octopus has a lifespan ranging between one and two years. ![]() The lab’s research includes fieldwork to collect poorly known animals, often by SCUBA diving and sometimes with remotely operated underwater vehicles. My Octopus Teacher showcases the bond between Craig Foster and a common octopus. His lab studies animal evolution, with a particular focus on better understanding our most distant animal relatives and the earliest events in the animal tree of life. My Octopus Teacher follows documentary film-maker Craig Foster as he dives in the ocean near his home on the southern shores of the Cape Peninsula to. Casey Dunn '05 PhD is Professor of Ecology and Evolutionary Biology at Yale and Curator of Invertebrate Zoology at Yale’s Peabody Museum of Natural History. ![]() ![]() One of Argentina Residenza’s great assets is the people: it’s not like you have to try hard to find a good place to eat around here, you're in the very heart of Rome. This isn’t one of Rome’s lavish old hotels, but a stylish and practical guesthouse, a place to recharge between sightseeing and wining and dining in the Eternal City, to linger over a simple but gourmet continental breakfast while planning the day’s activities. But that’s about the extent of the in-room luxury. Upgrade to a suite for extras like a Jacuzzi and a Nespresso machine. Each comes with a flat-screen TV, free wi-fi, a universal charger, a coffee and tea station, a bathtub and a separate glass-encased shower. Standard rooms are, well, standard, but smart and elegant, with high ceilings, parquet floors, heavy drapery and brand-new bathrooms. There’s no grand entrance here: a stay at the Argentina Residenza is more like being in a private apartment. If you have a camera with a zoom lens, all the better. You’ll see them from the windows of Argentina Residenza, a small and stylish guest house located on the third floor of one of the stately buildings that line the square. Hundreds of felines lounge around on the picturesque ruins of four ancient temples and the Theatre of Pompey, soaking up the sunshine and creating endless photo opportunities for passerby. These days, a couple of millennia later, the square is perhaps best known to tourists for its cat sanctuary. ![]() Beware the ides of March: it’s here, in the Roman piazza now known as Largo di Torre Argentina, that Julius Caesar was assassinated by his conspirators in 44 BC. ![]() Think of this as “taking the scenic route.” Taking the scenic route is how you are able to be seen as originating from a different location as opposed to your actual location. The connection is likely to be slower because you are making your data go through an extra path or paths. When you connect to a VPN, your upload and download speeds will almost always be slower. The same can be said for the majority of the Internet. You can take it to the track and put the pedal to the metal, but you can’t exactly do that in the middle of town… either because there’s not enough room or there is too much traffic in front of you to reach full speed. Consider it to be like owning and test driving a race car. The speed tests that they provide will typically be done within their network, meaning that they likely represent the best and the absolute maximum speed of what you can send/receive at your home… but it does not mean that you are guaranteed that maximum upload and download rate outside of your ISP’s network. ![]() Your Internet Service Provider promises “up to” a specific speed limit or bandwidth on their network. Unlike a car, you don’t have the option to hit the gas and ignore the speed limit. Additionally, there are always speed limits. ![]() To take the analogy a bit further – some of these streets or networks only have a limited number of lanes which means that only so much traffic can pass through at once. The same can be said for your data: it has to pass through multiple networks of varying size and capacity in order to get to the destination. Transit can be thought of in the following way - Imagine a car that has to travel from your home to your work: there are multiple streets and in some cases a highway that might have to be taken to get to the destination. For the purposes of this article, Transit is the entire path that your data has to travel. To answer what impacts speed, we need to first explain what is meant by the word Transit.įor you the end-user, Transit is the path data takes to get from one point to another. Although you may experience some speed loss while on the VPN, your VPN connection may be running faster than it appears. Quite often, however, the speed test server does not max out the available bandwidth because of many factors, including but not limited to, transit conditions between it and the speed testing server.Īs such, relying too heavily on just one or two speed tests can lead to incorrect assumptions and conclusions about the overall speed and performance of your connection to our VPN. The main reason running one or two of these quick speed tests is not reliable is because the speed test server you are testing our VPN server against, would actually have to be capable of reaching the full bandwidth or the download and upload speeds available from your internet connection and the VPN server to yield reliable results. Simply going to a speed test site and running one or two quick speed tests is not enough information and will not yield reliable results - more on why below. In order to get a good idea of exactly what is going on with your internet speed, it is critical that you get reliable information about your speeds while you are connected and on the VPN as well as getting reliable speed information when you are disconnected and off the VPN. |
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